According to the parents ratings, the percentage of responders for the reduction of irritability and or hyperactivity on the aberrant behavior checklist-community version abc-cv scale were slightly higher in the amantadine group but the difference over placebo was not deemed statistically significant p 0.
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amantadine undergoes n -acetylation, and about 5-15 of an absorbed dose is excreted in urine as acetylamantadine.
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