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pyridoxine b6 deficiency is sometimes observed in adults with high doses of isoniazid and is considered probably due to its competition with pyridoxal phosphate for the enzyme apotryptophanase.
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however, for pregnant women likely to have been recently infected or with high-risk medical conditions, especially hiv infection, isoniazid preventive therapy should begin when the infection is documented.
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following oral administration, isoniazid is absorbed rapidly from the gi tract.
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